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Mostrando postagens com marcador Transplante de órgãos. Mostrar todas as postagens
Mostrando postagens com marcador Transplante de órgãos. Mostrar todas as postagens

terça-feira, 16 de agosto de 2016

Incor supera marca de mil transplantes realizados desde 1985 Instituto do Coração do Hospital das Clínicas já fez 1.080 procedimentos. Primeiro transplante feito na instituição aconteceu em 1985.

01/08/2016 10h47 - Atualizado em 01/08/2016 13h43

Incor supera marca de mil transplantes realizados desde 1985Instituto do Coração do Hospital das Clínicas já fez 1.080 procedimentos.Primeiro transplante feito na instituição aconteceu em 1985.

Do G1, em São Paulo


Crianças transplantadas participam de evento no Incor (Foto: Mariana Lenharo/G1)Crianças transplantadas participam de evento no Incor (Foto: Mariana Lenharo/G1)
Desde o primeiro transplante realizado na instituição, em 1985, foram 564 transplantes de coração em adultos, 230 transplantes em crianças e 286 transplantes de pulmão.

De acordo com o cardiologista Roberto Kalil Filho, presidente do conselho diretor do Incor, a instituição poderia fazer ainda mais transplantes caso houvesse mais doadores de órgãos no país. "Em estrutura e captação de órgãos, se melhora a cada dia. Temos estrutura para isso, o problema é o doador. Tem doadores, mas precisamos de mais", diz Kalil.
O professor de história Elias Manoel da Silva, de 53 anos, foi o milésimo paciente a receber um transplante no Incor. Silva soube que precisaria de um transplante em 23 de julho de 2015 e passou pelo procedimento em 9 de setembro, período em que permaneceu internado na instituição.O professor Elias Manoel da Silva, de 53 anos, foi o milésimo paciente a receber um transplante no Incor; cirurgia foi em setembro de 2015 (Foto: Mariana Lenharo/G1)O professor Elias Manoel da Silva, de 53 anos, foi o milésimo paciente a receber um transplante no Incor; cirurgia foi em setembro de 2015 (Foto: Mariana Lenharo/G1)Heloísa Cardoso da Silva, de 3 anos, recebeu um coração novo há quase um ano e meio; seu pai, Ricardo Santos da Silva, diz a menina se desenvolve bem (Foto: Mariana Lenharo/G1)Heloísa Cardoso da Silva, de 3 anos, recebeu um coração novo há quase um ano e meio; seu pai, Ricardo Santos da Silva, diz a menina se desenvolve bem (Foto: Mariana Lenharo/G1)Participaram do evento para marcar a superação da marca de mil transplantes no Incor o ministro da Saúde, Ricardo Barros, o governador de São Paulo, Geraldo Alckmin e o secretário estadual de Saúde de São Paulo, David Uip.
Um grupo de manifestantes protestou contra as autoridades durante o evento, com cartazes que mencionavam Temer, Barros, Alckmin e Uip.
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Manifestantes protestam contra Temer, Alckmin e David Uip durante evento (Foto: Mariana Lenharo/G1)Manifestantes protestam contra Temer, Alckmin e David Uip durante evento (Foto: Mariana Lenharo/G1)
Mariana Lenharo
O Instituto do Coração do Hospital das Clínicas da USP (Incor) superou a marca dos mil transplantes. Foram realizados 1.080 procedimentos, segundo dados divulgados nesta segunda-feira (1º) pela instituição.
Ele destacou os avanços promovidos no transporte dos órgãos a serem transplantados no país. "Temos helicópteros e aviões do estado de São Paulo para captar órgãos à distância. Com o decreto de Temer, também podemos usar avião da FAB para esse transporte, o que promoveu uma melhora ainda maior."Isso corresponde a 40% de todos os transplantes de coração realizados no estado de São Paulo e 37% dos realizados no Brasil. O Incor fica na sétima posição mundial dos maiores centros de transplante cardíaco do mundo.
Em junho, o presidente em exercício, Michel Temer, ordenou que a Aeronáutica mantenha permanentemente à disposição um jato da Força Aérea Brasileira (FAB) para atuar no transporte de órgãos e tecidos para transplantes.
Milésimo paciente
Ele saiu do hospital no dia 8 de outubro. "Eu me sinto muitíssimo bem, nunca tive nenhum problema mais sério depois disso", diz o paciente. "Depois que há a morte de um ente, a doação é a coisa mais importante na vida. O morto leva um coração, dois pulmões, rins, pele, pâncreas. Tudo isso, se não é doado, morre. Quando é doado, salva vidas. É assim que eu vejo a doação."
Já no caso de Heloísa Cardoso da Silva, de 3 anos, a notícia de que precisaria de um transplante de coração veio antes do primeiro aniversário. Seu coração estava crescendo mais do que o normal, o que estava prejudicando a saúde da menina. O pai de Heloísa, Ricardo Santos da Silva, conta que foram quase 11 meses esperando o órgão até o transplante.
"Foi angustiante porque a gente sabia que a qualquer hora o coração poderia parar. O pouco que ele batia era suficiente só para respirar. Ela não ganhava peso, pelo contrário, perdia peso. O coração dela batia, 21%, 22%. Para a gente, era como se tivesse uma bomba relógio ali dentro que a qualquer momento poderia parar", diz Ricardo.
Hoje, um ano e cinco meses após o transplante, Heloísa é uma criança que brinca, corre, frequenta a escola e se desenvolve bem, segundo o pai.
Protesto

Participaram do evento para marcar a superação da marca de mil transplantes no Incor o ministro da Saúde, Ricardo Barros, o governador de São Paulo, Geraldo Alckmin e o secretário estadual de Saúde de São Paulo, David Uip.


Um grupo de manifestantes protestou contra as autoridades durante o evento, com cartazes que mencionavam Temer, Barros, Alckmin e Uip.

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Manifestantes protestam contra Temer, Alckmin e David Uip durante evento (Foto: Mariana Lenharo/G1)Manifestantes protestam contra Temer, Alckmin e David Uip durante evento (Foto: Mariana Lenharo/G1)





























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CEBID - Centro de Estudos em Biodireito

quarta-feira, 11 de maio de 2016

Nascent concerns about womb transplants





Bioethicists have sounded a note of caution about womb transplants after a failed attempt at the procedure in a US fertility clinic.
In late March a participant of an American trial had to have her recently transplanted womb removed. Ironically, the reverse-transplantation was necessitated by a common uterine infection unrelated to the initial operation.
Still, Some have used the failed operation as an opportunity to question the merits of the research. Southampton Law School lecturer Natasha Hammond-Browning doubts that the procedure has a net benefit for the women involved:   
“…I do not deny that for women without wombs who desire a uterus transplant, and receive one as part of one of the clinical trials that are happening, may well argue that their quality of life has been improved through the ability to experience one or two pregnancies. However, I believe that we need to ask: at what cost?...”
Other academics have enumerated various potential negative consequences that the procedure could have, and some suggest that even the ostensible benefits of the transplant have been misconstrued. As early as 2011 a group of researchers from Australia’s Macquarie University, discussed ethical problems surrounding the practice, noting, for example, that the limited nerve connections between the uterus and the recipient’s body may in fact entail an absence of the typical positive feelings experienced by a woman during pregnancy. The authors of that study did, however, note a certain inconsistency that would result from deny womb transplants to infertile women:
“Where a woman does not have a functioning uterus, it is far from clear how we might legitimately encourage use of a surrogate (with all its attendant difficulties) but withhold the opportunity to employ an (in principle) established surgical technique – namely, organ transplantation – in order to allow her to achieve a pregnancy ‘of her own’.”
US Researchers remain positive about the uterine transplant trials, despite the setbacks already encountered. The surgeon who is leading trials at the Cleveland Clinic, Dr. Goran Klintmalm said he and his doctors had discussed their failed transplant with his team. “What they experienced is something that helps us to fine tune our protocol and approach, to hopefully avoid having the same situation,” Dr. Klintmalm said.





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CEBID - Centro de Estudos em Biodireito

terça-feira, 29 de março de 2016

Primeira mulher a receber transplante de útero nos EUA teve que tirar órgão

09/03/2016 19h24 - Atualizado em 09/03/2016 19h25

Primeira mulher a receber transplante de útero nos EUA teve que tirar órgão

Segundo instituição, paciente teve complicações, mas passa bem.
Em nota, paciente agradeceu por orações e pensamentos positivos.

Do G1, em São Paulo
 Lindsey (que não quis divulgar seu sobrenome) e seu marido Blake apresentaram-se para a imprensa ao lado da equipe médica da Cleveland Clinic nesta segunda-feira; ela foi a primeira a receber um transplante de útero nos EUA  (Foto: Marvin Fong/The Plain Dealer via AP)Lindsey (que não quis divulgar seu sobrenome) e seu marido Blake apresentaram-se para a imprensa ao lado da equipe médica da Cleveland Clinic nesta segunda-feira; ela foi a primeira a receber um transplante de útero nos EUA, mas teve de retirar órgão (Foto: Marvin Fong/The Plain Dealer via AP)



























A primeira paciente que recebeu um transplante de útero nos Estados Unidos teve o órgão retirado devido a complicações, segundo nota divulgada nesta quarta-feira (9) pela Cleveland Clinic, instituição responsável pelo procedimento.
A cirurgia foi feita no dai 25 de fevereiro e, nesta segunda-feira, a clínica tinha anunciado que a paciente tinha uma boa evolução. Agora, as circunstâncias da complicação estão sendo investigadas, segundo a clinica.
"Enquanto isso tem sido difícil tanto para a aciente quanto para a equipe médica, Lindsey passa bem e está se recuperando. O estudo, que planeja incluir 10 mulheres, está em andamento com o compromisso de obter avanço da pesquisa médica e uma opção a mais para mulheres e suas famílias", afirma a nota divulgada ela instituição.
"Infelizmente, eu perdi o útero devido a complicações. No entanto, eu estou bem e agradeço por todas as preces e pensamentos positivos", afirmou Lindsey, paciente que não quis ter o sobrenome divulgado, também em nota.
Caso de sucesso na Suécia
Em 2014, em um feito inédito da medicina, umamulher da Suécia deu à luz depois de receber um transplante de útero.
A mãe, de 36 anos, recebeu o útero de uma amiga próxima de sua família no ano passado. Seu bebê, um menino, nasceu prematuro, mas saudável.
Na Turquia, houve um caso de uma paciente que, depois do transplante de útero, ficou grávida, mas acabou perdendo o bebê.
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CEBID - Centro de Estudos em Biodireito

quinta-feira, 3 de dezembro de 2015

A quiet revolution in organ transplant ethics




Earlier this week New York University Langone Medical Center announced the successful completion of the most extensive face transplant to date. It was performed on a volunteer firefighter from Mississippi who suffered a full face and scalp burn in 2001 when a roof collapsed on him during a rescue search.
It was a triumph of modern medicine, but it was also a reminder of the questions which swirl around transplant surgery. Organ transplants have always been regarded as life-saving interventions. Without a heart, lungs or kidneys patients die. But surgeons are now transplanting non-vital body parts, such as the face, uterus, voicebox, penis, ovary and fallopian tube, which require a fresh look at standards of medical ethics, according to bioethicist Art Caplan, of New York University Langone Medical Center. He writes in his column in Forbes magazine:
Unlike heart, liver, kidney and lung transplants, they are being done to enhance the quality of life or to palliate suffering. Some are being done not to save lives but to allow individuals to create new ones. These are manifestly ethical goals. But the shift away from saving lives to making them better involves a shift in the ethical thinking that has long formed the foundation of organ transplantation. They require doctors, patients, regulators and the rest of us to rethink the risk and benefit ratio represented by these new forms of transplant.
Powerful immosuppressive drugs are an integral part of any transplant. But these have side-effects, including organ failure, which shorten a patient’s life span. How ethical is it to increase a patient’s quality of life by shortening his quantity of life? 
Transplanting a face to allow a person to reenter society without stigma or scorn is a wondrous thing. Allowing a woman to bear a child in a society or state where gestational surrogacy is not even an option will find some eager to try. But the new world of transplant requires revisiting some old ways of ethical thinking to help grapple with an entirely new set of opportunities and challenges.





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CEBID - Centro de Estudos em Biodireito

terça-feira, 24 de novembro de 2015

This Gay Man Sold A Kidney To Escape Iran


This Gay Man Sold A Kidney To Escape Iran

Danial risked his life to get to Turkey, trusting that the refugee system would look after him when he got there. Instead, it was just the beginning of his problems. Lester Feder reports for BuzzFeed News.
DENIZLI, Turkey — There was only one way Danial could think of to get out of Iran: He would have to sell his kidney.
He got the idea from fliers offering cash for organs, which he had seen pasted to walls in the northern Tehran neighborhood of Tajrish. Danial had vague memories of them tacked near the bus stop where he’d get off to go to his painting classes. Those classes were how he kept his dream of becoming an artist alive, despite the fact that he’d never been allowed to go to school.
His situation felt hopeless. His mother had confronted him about being gay one December morning in 2013. By noon he had fled the family home, taking nothing but the clothes on his back and 50,000 rials — about $2 — in his pocket. His boyfriend lived in the city of Isfahan six hours to the south, but it wouldn’t be safe for them to stay together even if he could afford a bus ticket. Danial had a job at a glass factory in southern Tehran — he still has scars on his emaciated body from where the furnaces burned him — but it didn’t pay enough for him to rent an apartment on his own, let alone escape across the border into Turkey.
“I had no way forward, no way backwards — I just wanted to escape from that place,” Danial said.
For most Iranians, getting to Turkey would be as simple as buying a plane ticket, which can cost less than $200; a few hundred LGBT Iranians make this trip every year because it’s an easy jumping-off point to a new life in the West. Iranian passport holders don’t need a visa to enter Turkey, and the United Nations fast-tracks LGBT refugees for resettlement because it considers them especially vulnerable.
“I just wanted to escape from that place.”
But Danial couldn’t get an Iranian passport. He was the son of an Afghan, one of the estimated 3 million who have come to Iran since the 1980s, fleeing decades of war and looking for work. The Iranian government wants them out; it generally doesn’t grant their children citizenship and deliberately makes it hard for them to access basic services — that’s why Danial hadn’t gone to school. Without documents, Danial could only get to Turkey by hiring smugglers to sneak him across the border, which would cost a seemingly impossible amount: around $1,000.
Selling his kidney turned out to be harder than Danial had hoped. He initially marched into a government-run clinic on Valiasr Street in the heart of Tehran and announced he wanted to sell his kidney, but they wouldn’t even let him past the front door because he had no ID to prove he was an adult.
Then he got a break, of sorts. A man followed him out of the clinic and introduced himself as the uncle of an 8-year-old boy who needed a kidney transplant. They had a short conversation establishing that Danial had a compatible blood type, and the man offered him 50 million rials, about $1,700.
“I had no other options, so I accepted,” Danial said.
Like millions of other refugees from across the region, Danial saw going to Turkey and then on to the West as his only path to the future. But as their numbers have grown — from around 25,000 to over 2 million in just four years — the system for processing refugees in Turkey is being strained to breaking point. Danial sold his kidney to get to Turkey, trusting the system would take care of him once he got there. Instead he discovered that he had to fend for himself, navigating a system so complicated that the refugees with the fewest resources can easily fall through the cracks.


Danial had met his boyfriend, Parsa, at a birthday party for a mutual friend about two years before he fled his family. (Both men asked to be identified by their nicknames out of fear for their safety.)
Parsa, a 21-year-old aspiring musician with an electric, angular smile, was DJing, and he chatted Danial up about a painting of a flower he’d made as a birthday present for their friend. Parsa was about four years older than Danial and had also struggled to pursue a career in the arts after his family forced him to abandon his studies. They started dating soon after but could see each other only occasionally. When they couldn’t be together, Danial and Parsa traded text messages every night before bed.
“I could not go to sleep without those messages,” said Danial, whose high cheekbones make him look pixieish when he smiles. He suspects the messages were what tipped his family off to their relationship. “I kept every single one.”
So Parsa was alarmed when he hadn’t heard from Danial in the month after he left his mother’s house. Danial finally broke the silence with a short message telling Parsa to meet him the next day at a hospital in Tehran. Parsa was frantic when he arrived, convinced Danial had been in an accident.
But Danial looked perfectly healthy when he found him. Parsa was furious when he learned what he planned to do.
“For how much money did you put your life in danger?” 
“For how much money did you put your life in danger?” he recalled shouting at Danial. He started arguing with the doctors: “With what authorization would you operate on someone who has no one with him and cut a part of his body — how could you let him decide to do such thing?”
Danial had known Parsa would react this way, which is why he kept the plan a secret until all the arrangements were made; he’d even rented a motel room for his recovery. Now it was too late to back out. The buyer had already invested around $350 for medical tests to confirm Danial’s kidney would match, and they had no way to repay it. The couple also felt for the child who was due to receive his kidney, whom they saw being wheeled into surgery.
“He was a very small boy who had so many scars all over his body — his kidneys were failing since he was born,” Parsa remembered.
Danial realized what a terrible mistake he’d made immediately after his surgery. His stitches became infected, and he burned through some of his profits to have them treated. Months flew by and he was still not well enough to travel; the bill for his room was beginning to add up even though he was paying just $14 per night.
After six months, he had just about $1,060 left, and he was still very weak.
“I had no way back to undo what I had done,” Danial said. “I realized I had even more problems.”
Danial shows the scars on his body left by the operation to remove one of his kidneys. Bradley Secker for BuzzFeed News
Many LGBT Iranians who seek asylum in Turkey simply fly to Ankara and go straight to the office that registers new refugees. Iranians make up the majority of the 700 LGBT people currently in the pipeline for resettlement who have identified themselves to the local office of the United Nations High Commissioner for Refugees (UNHCR). One NGO that supports queer Iranian refugees reports getting an average of 30 new requests for help every month.
Hundreds of LGBT Iranians have been resettled in the West — especially in Canada — over the past several years, and many arrive in Turkey with a good deal of information about how to navigate the process. It now generally takes about two years for them to get a ticket out of Turkey even though UNHCR considers LGBT people especially vulnerable and fast-tracks them for resettlement. Many LGBT Iranians have had friends who’ve already been resettled or at least know the general outline of the process; some save up for the wait before they come or even have support from their families, making the wait easier to bear.
But Danial had to travel before he was really ready. If he waited any longer to recover his strength, he wouldn’t be able to afford the smuggler’s fee. Parsa would have to meet him in Turkey. He was an Iranian citizen and so would be able to fly to Turkey legally, but it would take a little time for him to get his passport issued.
In early August 2014, two smugglers guided Danial and a few others on a four-day trek through mountains and forests from the Iranian town of Maku to Van in southeastern Turkey. At night they would sleep in clearings in the brush. Despite Danial’s fragile condition, he had to run in places where they might encounter border patrols.
In Van, the smugglers put him on a bus to Ankara. As the bus left the station, he realized that he was now totally on his own and had very little idea about what would happen next. He could speak no Turkish. He didn’t even know that Turkey used a different currency than Iran and got cheated out of half his remaining cash when a money changer took advantage of his ignorance. He had a sheaf of papers documenting his kidney surgery, but nothing to prove his identity. He couldn’t even definitively tell refugee officials how old he was — his best guess was around 21 or 22 by that point — because his family never told him his birthdate.
“The only thing I knew was there is something called the ‘United Nations,’” he said. “I thought because we are gay and we are different, there is nothing to be scared of.”


The center of the Turkish city of Denizli, home to many LGBT Iranian asylum seekers. The rooster is Denizli’s official symbol. Bradley Secker for BuzzFeed News
Danial followed a group of other refugees from the bus station in Ankara to the office of the Association for Solidarity with Asylum Seekers and Migrants (ASAM), an NGO that registers refugees on behalf of UNHCR.
Others who passed through that ASAM office around the same time described it as an off-white building in a well-off residential neighborhood that appeared to have been built for the time before Turkey became one of the world’s top destinations for refugees. Iranians and Afghans waited alongside Syrians and people from a number of other Arab countries in chaotic lines that streamed out the front door. Refugees choked the narrow hallways inside, waiting to be summoned for processing. The walls echoed with the cries of screaming children and exuded the smell of the thousands who had passed through the building in a desperate search for shelter.
Danial wound up in line with a bunch of Afghans, who advised him to say he was Afghan when his turn came to explain his case. “They told me Afghans are being accepted easily [as refugees], compared to Iranians,” he said. “So I just said I was Afghan and gay — I had nothing else to say and I had no documents.”
“They told me Afghans are being accepted easily… So I just said I was Afghan and gay.”
This proved to be a serious mistake, according to Saghi Ghahraman, director of the Toronto-based Iranian Queer Organization (IRQO), which assists Iranians with the refugee process and ultimately took up Danial’s and Parsa’s cases. Most of her Iranian clients leave the ASAM office with a date for their first face-to-face meeting with a UNHCR official — called a pre-interview — but Danial left without any appointment at all.
It’s impossible to know for sure if Danial’s case would have progressed differently if he’d said he was Iranian. But a number of refugee advocates told BuzzFeed News that UNHCR appears to have generally put all Afghan cases “on hold,” largely because the countries that take refugees from Turkey allocate very few slots to people of Afghan origin.
Danial “didn’t get a pre-interview date at that time because he said he was Afghan,” Ghahraman said.
Selin Unal, spokesperson for UNHCR-Turkey, did not comment directly on this case, but she denied that the agency is treating Afghan refugees differently than any others in an email to BuzzFeed News.
“UNHCR continues to process vulnerable Afghan asylum seekers and refugees, and provides protection assistance to those in need in collaboration with the Turkish government and NGOs,” she said. But, she said, “Resettlement opportunities depend on quotas [set] by resettlement countries.”
Parsa, who showed up at ASAM on Dec. 18 with an Iranian passport, sailed through the system compared to Danial. He had his first interview with UNHCR on Jan. 27, was granted refugee status by the agency in April, and his paperwork was with the Canadian government by the end of June to be considered for resettlement.
His case may have been accelerated because they enlisted the help of IRQO’s Ghahraman shortly before he registered. Danial said they learned about IRQO by chance when they struck up a conversation with some trans refugees they overheard speaking Farsi in a public park, and it took a couple of tries before they convinced Ghahraman about the urgency of their case. Her intervention also nudged Danial’s case forward — UNHCR brought him in for his pre-interview in January, after she described his case to an agency contact.
But in the months after Parsa learned he might go to Canada, no call came telling Danial he was going too.
They had spent much of their year in Turkey on the edge of homelessness. Danial had followed other refugees he met at the ASAM office in Ankara to the city of Denizli, a fast-growing city of about 600,000 people nestled at the feet of dramatic mountains in southeastern Turkey. Turkey bars refugees from most countries from living in major cities like Istanbul, and Denizli had become a major hub for Iranians — especially LGBT Iranians — awaiting resettlement. Denizli’s downtown is clean and new, but its economy is built on textile manufacturing — allowing refugees who are prohibited from working legally to eke out a living under the table in sweatshops.
The work was hard on Danial, whose urine sometimes turned red from internal bleeding at the end of 12-hour days hauling bolts of fabric that could weigh more than he did. Sometimes the bosses wouldn’t pay the wages they owed, and Danial and Parsa were thrown out of one apartment after another.
Danial became convinced he would never be freed from this purgatory and worried Parsa would give up his chance to go to Canada in order to stay with him. He grew so weak that his dark black hair began falling out in patches, making his scalp look almost leopard-spotted. UNHCR referred him to a psychiatrist, who said he couldn’t do anything to advance his case and instead offered him a prescription for anti-anxiety pills.
“My case will not end up anywhere and [Parsa] is stuck because of me,” Danial remembered thinking to himself one night when Parsa went out to buy bread. “I knew that if I have to stay here, he will stay with me and not leave.”
“I wanted him to go and live free,” Danial said, “so I took all of those pills.”
Danial was unconscious when Parsa found him. Parsa frantically searched for a neighbor who knew the number to call for an ambulance and spoke enough Turkish to give them the address. The paramedics would not let him ride with Danial in the ambulance, and he had to be careful about how he showed his feelings because they lived in a building filled with other Iranian refugees who they were terrified would figure out they were a couple.
“It was like a nightmare,” Parsa said. The doctor said that Danial could die anytime within the next three days — but if he survived that period he would live.
Danial survived, but when the couple spoke to BuzzFeed News two weeks after his suicide attempt, he was feeling more alone than ever.
“No one can ever help us,” Danial said. “What does U.N. believe in? Why does U.N. exist? … When they don’t help me, who are they helping?”
“What does U.N. believe in? Why does U.N. exist?”
On Oct. 12, Danial finally got a piece of good news: He would also be considered by Canada for resettlement.
Their problems aren’t over yet; it often takes about another year from this step in the process before a refugee actually boards a plane. But at least the end is in sight.
But their story shows just how easily the most vulnerable refugees can fall through the cracks in the system that should be trying to help them most, said Ghahraman. If they hadn’t found an advocate with contacts inside UNHCR, Danial might never have even learned that it was a mistake to say he was Afghan, let alone had a chance to correct it.
Many of the people who work in UNHCR are doing it for all the right reasons, Ghahraman said, and she has seen individuals leap into action when they learn of a refugee who needs extra help. But the system as a whole is set up to comply with “the policy and the rules and laws —nobody helps somebody out just based on humanity,” she said.
Danial is still painting while he waits — mostly pictures of flowers — though he was using up the last of canvases and had no money for more. Other than his medical records, just about the only other things he brought with him from Iran were 12 small tubes of oil paint.
“It’s more than a year that I am waiting in Turkey; for someone who is in good situation, this might not feel like [even] a month, but for me it feels like years — I cannot take it anymore,” Danial said. “My art is painting and I really can’t do anything else.”

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CEBID - Centro de Estudos em Biodireito

terça-feira, 3 de novembro de 2015

Gene editing technique makes pig organ transplants possible


Scientists are moving closer to transplanting animal organs into human beings. A team led by George Church, of Harvard, has used the CRISPR gene editing technique to remove all 62 copies of a pig retrovirus which is dangerous for humans.
This is a significant step on the road to generating pig organs for possible xenotransplantation. Worldwide, human organs for transplant are in short supply. While pig organs have long been considered a viable option, porcine endogenous retroviruses (PERVs) -- found in all pigs' DNA - can be transmitted to humans where they may cause disease. This has resulted in a worldwide moratorium on pig-to-human transplants.
In the past, strategies for reducing the risk of PERV transmission to humans during transplantation have had limited success. But by using the CRISPR technique, Church and his colleagues believe that they have reduced PERV infectivity by 1000-fold.
Technically, the research is very impressive. In an article in Science, the researchers reported that they had managed to modify more than 60 genes in pig embryos — ten times more than have been edited in any other animal. According to Nature, A biotech company that Church co-founded to produce pigs for organ transplantation, eGenesis in Boston, is working on making the process as cheap as possible.



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CEBID - Centro de Estudos em Biodireito

quinta-feira, 22 de outubro de 2015

El ‘borrado’ genético, primer paso para trasplantes de cerdo a humano



Trasplante de hígado y riñones
Trasplante de hígado y los riñones de un donante en un hospital / REUTERS
Incluso en España, el país líder en trasplante de órganos, hay siempre más demanda que oferta de ese material vital, y el problema es aún peor en otros países. El cerdo se considera una de las fuentes más prometedoras de órganos, pero las investigaciones están paradas por un grave problema: su genoma contiene docenas de retrovirus que pueden activarse e infectar al receptor del trasplante. En un importante paso para resolverlo, un grupo de investigadores de Harvard han utilizado la edición genómica para inactivarlos a todos. Y han comprobado en células humanas que la infectividad se pierde, o al menos se reduce en más de 1.000 veces.
Los retrovirus son un escollo particularmente espinoso. Mientras que los virus convencionales pueden limpiarse criando a los cerdos en condiciones de bioseguridad, los retrovirus siguen teniendo sus genomas integrados en el genoma porcino, y desde ahí se pueden reactivar tras el trasplante, infectando a las células humanas y causando una catástrofe en el cuerpo del paciente. Los intentos de eliminarlos habían tenido hasta ahora unos resultados muy modestos, en el mejor de los casos.
El genetista George Church y sus colegas de la Facultad de Medicina de Harvard, el Instituto Wyss de Igeniería Inspirada en la Biología (ambos en Boston) y la Universidad de Zhejiang en Hangzhou (China) han utilizado ahora la técnica crispr de edición genómica –cuyas dos inventoras recibieron el último premio Princesa de Asturias— para inactivar todas las copias del genoma retroviral que están integradas en el genoma del cerdo. Presentan sus resultados en la revista Science.
Church y sus colegas tuvieron que hacer antes un minucioso trabajo de taxonomía molecular para determinar el número exacto de genomas retrovirales en el genoma porcino –resultaron ser 62— y el tipo preciso al que pertenecen. La técnica crispr es extremadamente eficaz para eliminar o modificar un gen, pero nunca se había utilizado para inactivar 62 de una tacada. Esto es en sí mismo un notable logro tecnológico.
La técnica 'crispr' es extremadamente eficaz para eliminar o modificar un gen, pero nunca se había utilizado para inactivar 62 de una tacada
Pese a que los retrovirus son muy variados, todos tienen una estructura genética inconfundible, con tres genes esenciales que se ocupan de replicar su genoma, insertarlo en el ADN de su huésped –sea un cerdo o una persona—, fabricar las proteínas de su cubierta y ensamblar todo ello como partículas infecciosas. Uno de los tres genes se llama pol (de polimerasa, la enzima que gestiona la parte genética del ciclo del virus), y contiene una secuencia extremadamente conservada en los 62 retrovirus porcinos, que corresponde al centro catalítico de la enzima. Contra ella han dirigido los científicos su arma poderosa.
La técnica crispr de edición genómica está revolucionando los laboratorios de genética por su simplicidad y enorme eficacia. Se conoce sobre todo porque permite manipular el genoma humano, y por tanto es la gran esperanza actual para corregir las 5.000 enfermedades hereditarias descritas, entre ellas las enfermedades raras, cada una de las cuales afecta a pocas personas, pero que en conjunto suponen un grave lastre sanitario para una fracción significativa de la población.
Pero también tiene muchos otros usos, como demuestra el trabajo actual. El gran poder de crispr es que se basa en el mismo centro lógico de la genética, la complementariedad entre las letras o bases del ADN (A con T, C con G), que le permite dirigirse contra una secuencia concreta (GATACCA...) para modificarla o –como en este caso— destruirla. Al elegir como diana una secuencia muy conservada del gen pol retroviral, Church y sus colegas han podido inactivar los 62 retrovirus integrados en el genoma del cerdo con solo dosdardosgenéticos dirigidos contra ellos.
Las aplicaciones clínicas no serán directas –no veremos trasplantes de órganos porcinos a pacientes en la legislatura que salga de las próximas elecciones generales—, pero los investigadores esperan que el avance, al menos, desbloquee una línea de trabajo que se había estancado ante el obstáculo formidable que suponían los retrovirus del cerdo. Un obstáculo que ha caído a manos de una técnica no menos formidable de dición genómica.

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CEBID - Centro de Estudos em Biodireito

terça-feira, 6 de outubro de 2015

Reino Unido autoriza primeiros transplantes de útero no país

30/09/2015 05h00 - Atualizado em 30/09/2015 05h00

Reino Unido autoriza primeiros transplantes de útero no país

Procedimento experimental já foi feito na Suécia, Turquia e Arábia Saudita.
Há um ano, sueca com útero transplantado deu à luz, em feito inédito.

Do G1, em São Paulo
Bebê nasceu em Gotemburgo, na Suécia (Foto: The Lancet/AP)Primeirio bebê nascido de uma mãe com útero transplantado: caso ocorreu em 2014 em Gotemburgo, na Suécia (Foto: The Lancet/AP)
Pesquisadores do Reino Unido receberam, nesta terça-feira (29), autorização para fazerem transplante de útero em 10 mulheres no país. Segundo o jornal "The Guardian", o ensaio clínico foi aprovado por um comitê de ética do Imperial College London e a equipe de pesquisa já identificou mais de 100 candidatas que atendem ao perfil buscado pelo estudo.
Na Turquia, houve um caso de uma paciente que, depois do transplante de útero, ficou grávida, mas acabou perdendo o bebê.O procedimento, já feito de maneira experimental na Suécia, Turquia e Arábia Saudita, traz esperança para mulheres que nasceram sem útero ou que perderam o órgão devido a um problema de saúde. Em setembro de 2014, uma sueca de 36 anos que recebeu um útero doado por uma amiga da família deu à luz um bebê saudável, provando o sucesso da técnica.
Segundo os envolvidos no projeto, caso o ensaio clínico seja bem sucedido, o primeiro bebê britânico gerado como resultado de transplante de útero poderia nascer entre 2017 e 2018.
"Como vimos no programa de transplante de útero extremammente bem-sucedido realizado por nossos colegas na Suécia, essa operação é claramente uma opção viável para aquelas mulheres que, de outra forma, não teriam nenhuma chance de gerar seu próprio bebê", afirmou o ginecologista Richard Smith, líder da equipe de pesquisa.


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CEBID - Centro de Estudos em Biodireito